Abstract
BackgroundThe prevention of catheter-related complications is nowadays an important topic of research. Flushing catheters is considered an important clinical procedure in preventing malfunction and several complications such as phlebitis or infection. Considering the latest guidelines of the Infusion Nurses Society, the flushing should be carried out both pre- and post-drug administration, requiring different syringes (with associated overall increased times of preparation/administration of intravenous medication by nurses, and also increasing the need for manipulation of the venous catheter).Methods/designA multi-centre, two-arm randomised controlled trial with partially blinded outcome assessment of 146 adult patients. After eligibility analysis and informed consent, participants will receive usual intravenous administration drugs with flushing procedures, with a double-chamber syringe (arm A) or with classic syringes (arm B). The outcomes assessment will be performed on a daily basis by an unblinded ward team, with the same procedures in both groups. Some main outcomes, such as phlebitis and infiltration, will also be evaluated by nurses from a blinded research team and registered once a day.DiscussionThe study outlined in this protocol will provide valuable insight regarding the effectiveness and safety of this new medical device. The development of this medical device (dual-chamber syringe, for drug and flush solution) seems to be an important step to facilitate nurses’ adoption of good clinical practices in intravenous procedures, reducing catheter manipulations.Trial registrationClinicalTrials.gov, NCT04046770. Registered 13 August 2019.
Highlights
The prevention of catheter-related complications is nowadays an important topic of research
The study outlined in this protocol will provide valuable insight regarding the effectiveness and safety of this new medical device
The insertion of a peripheral intravenous catheter (PIVC) is the most frequent invasive procedure performed in nursing clinical practice
Summary
The prevention of catheter-related complications is nowadays an important topic of research. Flushing catheters is considered an important clinical procedure in preventing malfunction and several complications such as phlebitis or infection. The insertion of a peripheral intravenous catheter (PIVC) is the most frequent invasive procedure performed in nursing clinical practice. These invasive devices are inserted into patients’ peripheral veins and enable the intravenous administration of fluids, blood products, and drugs directly into the bloodstream [1, 2]. Phlebitis (irritation or inflammation of the vein wall, associated with warmth, tenderness, erythema, or palpable cord) is the most frequent PIVC-related complication, which may have mechanical, chemical, or bacterial causes [5, 13]. Occlusion is defined as any circumstance in which the PIVC is not able to be flushed or infuse fluids/medications and it is a clinical sign of catheter malfunction [21]
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