Abstract
Aim: Blood culture (BC) sampling and antibiotic administration are common practices in Neonatal Intensive Care Units(NICUs). However, false positive BC results might affect clinician’s decision and lead to inappropriate antibiotic treatments. The aim of this study was to investigate the effect of double culture on clinical application.
 Material and Methods: The study was conducted retrospectively. The blood culture results of the patients admitted to the NICU between 2016-2019 were analyzed. Considering sepsis before 2017, we took only one sample from the patient. After this period, we started to take double blood cultures. Time frames of BCs were investigated to two groups as early and late onset sepsis fistly, and then subgroups as; a-) Group 1, BCs in the first 24 hours, b-)Group 2, between 24 to 72 hours, and c-)Group 3, after 72 hours. 
 Results: Total of 1747 BC samples were taken in study. Majority of BCs were in Group 3(62%). Male/female ratio was 1.3:1. Staphylococcus Epidermidis(S. Epi) was major source for the contamination. But, by taking dBCs, we were able to eliminate most S.Epi contamination in Group 2 (11%vs.3%) and in Group 3(41%to14%). We were able to identify some resistant Gr(-) pathogens in one arm although the other arm was negative, by taking dBC.
 Conclusions: Our study indicates that dBC policy in NICUs could help to clinicians for judicious decision in antibiotic use and decrease unnecessary antibiotic exposure of infants. Also it could be enable to detect some highly pathogen microorganism easily.
 Key words: Newborn, Septicemia, Blood culture, Coagulase Negative Staphylococci, contamination
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