Abstract
Efficacy of new antiinflammatory analgesic agent, 31252-S for the pain and inflammatory symptoms after tonsillectomy of children was investigated by double blind method in comparison with placebo.The results obtained were as follows.1) The effectiveness ratio was 60.5% for 31252-S, 35.6% for placebo.As a result of analysis of variance of the cumulative type, a significant difference was observed between the drugs (P<0.01).2) With respect to symptoms, a significant difference between 31252-S and placebo was observed on the 2nd day (P<0.05), as a result of canonical discriminant analysis.It was found that this difference in efficacy was due to the effectiveness of 31252-S on spontaneous pain, swallowing pain, redness and fever.3) No side effects which demanded particular attention were observed.The relationships among efficacy and body weight, efficacy and weight of tonsil extirpated, efficacy and blood picture were considered.
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