Abstract
Radiolabeled somatostatin analogues, including octreotate have been used for targeted radiotherapy of neuroendocrine tumors such as lymphoma, breast cancer, small-cell lung cancer and melanoma. In this paper, studies on the optimization of the production of 177Lu, 166Ho and 153Sm radionuclides in Pakistan Atomic Research Reactor (PARR-I) and the investigations on the labeling of DOTA-Tyr-3 Octreotate with 131I, 177Lu, 166Ho and 153Sm have been reported. The labeled DOTA-Tyr3-Octreotate complexes were found to be stable in acetate/ascorbate buffer and saline at room temperature (18–22°C). The biodistribution studies of 177Lu-DOTA-Tyr-3 Octreotate in rat model indicated that the critical organ for this complex was the pancreas and the excretion route was through kidney.
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