Abstract
Determination of intrafraction motion in stereotactic body radiation therapy (SBRT) of non-small-cell lung cancer (NSCLC) usually involves generating an internal target volume (ITV) based on target segmentation in every one of the 10 phases of a 4-dimensional computed tomography (4DCT) dataset which increases dosimetry work load substantially. This study explores the feasibility of using a smaller number of phases to compile an ITV to get equivalent results.
Highlights
Stereotactic body radiation therapy (SBRT) is gaining wide clinical acceptance in the management of early nonsmall-cell lung cancer [1,2,3]
Stereotactic Body Radiation Therapy (SBRT) involves the delivery of ablative doses of external radiation therapy in a hypofractionated scheme, typically with 30-60 Gray (Gy) delivered in 1-5 fractions. Such high doses of radiation require precise and accurate delineation of the gross tumor volume (GTV) in order to protect surrounding critical structures while giving a tumorcidal dose to the entire tumor. This is usually best achieved through the acquisition of a four dimensional computed tomography (4DCT) scan to help in the delineation of an internal target volume (ITV) that will account for the intrafraction motion of the tumor [4]
It is important to note that abdominal compression was tolerated well by the patients as this was customized for each patient
Summary
Stereotactic body radiation therapy (SBRT) is gaining wide clinical acceptance in the management of early nonsmall-cell lung cancer [1,2,3]. SBRT involves the delivery of ablative doses of external radiation therapy in a hypofractionated scheme, typically with 30-60 Gray (Gy) delivered in 1-5 fractions. Such high doses of radiation require precise and accurate delineation of the gross tumor volume (GTV) in order to protect surrounding critical structures while giving a tumorcidal dose to the entire tumor. This is usually best achieved through the acquisition of a four dimensional computed tomography (4DCT) scan to help in the delineation of an internal target volume (ITV) that will account for the intrafraction motion of the tumor [4].
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