Abstract
Gold nanoparticle-aided radiation therapy (GNRT) is an emerging treatment modality currently under development, based on the following observations: a) high tumor specificity of gold nanoparticles due to passive extravasation; b) significant tumor dose enhancement during x-ray irradiation as a result of increased photoelectric absorption due to high atomic number (Z) of gold. GNRT may provide new options to deal with a number of clinical challenges such as a dose escalation beyond the current limit, a more effective management of radio-resistant tumors, etc.
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