Abstract
High dose rate (HDR) brachytherapy is one of the accepted treatment modalities in gastro‐intestinal tract and bladder carcinomas. Considering the shortcoming of contact brachytherapy routinely used in gastrointestinal tract in treatment of big tumors or invasive method of bladder treatment, an intraluminal applicator with the capability of insertion into the tumor depth seems to be useful. This study presents some dosimetric evaluations to introduce this applicator to the clinical use. The radiation attenuation characteristics of the applicator were evaluated by means of two dosimetric methods including well‐type chamber and radiochromic film. The proposed 110 cm long applicator has a flexible structure made of stainless steel for easy passage through lumens and a needle tip to drill into big tumors. The 2 mm diameter of the applicator is thick enough for source transition, while easy passage through any narrow lumen such as endoscope or cystoscope working channel is ensured. Well‐chamber results showed an acceptably low attenuation of this steel springy applicator. Performing absolute dosimetry resulted in a correlation coefficient of R=0.9916(p‐value≈10−7) between standard interstitial applicator and the one proposed in this article. This study not only introduces a novel applicator with acceptable attenuation but also proves the response independency of the GAFCHROMIC EBT films to energy. By applying the dose response of the applicator in the treatment planning software, it can be used as a new intraluminal / interstitial applicator.PACS number: 87.53.Bn, 87.53.Jw, 29.40.Cs
Highlights
154 Hariri Tabrizi et al.: Dosimetry of a novel High dose rate (HDR) brachytherapy applicator with advanced unresectable cancer[2] who are indicated with tumor sizes deeper than 9 cm
For all of the four brachytherapy capable sites recognized in gastrointestinal tract, use of endoscope for inserting the applicators is defined.[7]. As a result, an applicator was designed with the capability to travel a long distance through lumens of endoscope or cystoscope, while it can be inserted into the predetermined depth of tumor
A novel two-purpose HDR brachytherapy applicator was proposed with the application in gastrointestinal tract or bladder or any luminal part of the body
Summary
154 Hariri Tabrizi et al.: Dosimetry of a novel HDR brachytherapy applicator with advanced unresectable cancer[2] who are indicated with tumor sizes deeper than 9 cm. Considering dose fall in this distance leads to an idea for inserting the applicator to the tumor depth, but without a need to perform surgery. The candidates for interstitial brachytherapy of bladder who have solitary and histologically confirmed transitional cell carcinoma of ≤ 5 cm in diameter[15], undergo an invasive method of applicator insertion. For all of the four brachytherapy capable sites recognized in gastrointestinal tract, use of endoscope for inserting the applicators is defined.[7] As a result, an applicator was designed with the capability to travel a long distance through lumens of endoscope or cystoscope, while it can be inserted into the predetermined depth of tumor. The dose distribution around this novel applicator was studied
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