Abstract
Background: Intensity Modulated Radiation Therapy (IMRT) is currently employed as a major arm of treatment in multiforme glioblastoma (GBM). The present study aimed to compare 3D-CRT with IMRT to assess tumor volume coverage and OAR sparing for the treatment of malignant gliomas. Materials and methods: We assessed 22 anonymized patients datasets with High Grade Glioblastoma who had undergone post-operative Intensity Modulated Radiotherapy (IMRT) and 3D Conformal Radiotherapy (3D-CRT), This study will compare and contrast treatment plans Rapidarc and 3D-CRT to determine which technology improves significantly dosimetric parameters. Results: Plans will be assessed by reviewing the coverage of the PTV using mean, maximum and minimum doses while the OAR doses will be compared using the maximal doses for each, as set out in the QUANTEC dose limits. Conclusion: The use of IMRT seems a superior technique as compared to 3D-CRT for the treatment of malignant gliomas having the potential to increase the dose to the PTV while sparing OARs optimally.
Highlights
Intensity Modulated Radiation Therapy (IMRT) and Three Dimensional Conformal Radiation Therapy (3D-CRT) are both very promising techniques for the thhhe treatement of brain tumors
The use of IMRT seems a superior technique as compared to 3D Conformal Radiotherapy (3D-CRT) for the treatment of malignant gliomas having the potential to increase the dose to the predicted target volume (PTV) while sparing Organs at Risk (OAR) optimally
The dosimetric coverage of the predicted target volume (D95) generated by the two techniques was almost fixed for each patient with an average compliance index for the Volumetric Modulated Arc Therapy (VMAT) of 0.9884 ± 0.010 and of 0.9894 ± 0.011 for the 3D-CRT in order to have a significant comparison for other dosimetric parameters
Summary
Intensity Modulated Radiation Therapy (IMRT) and Three Dimensional Conformal Radiation Therapy (3D-CRT) are both very promising techniques for the thhhe treatement of brain tumors. From the dosimetric standpoint, Three Dimensional Conformal Radiation Therapy (3D-CRT) and IMRT seem to provide similar results in terms of target coverage, while IMRT, regardless of the employed technique, is better in terms of dose conformity, in reducing the maximum dose to the organs at risk (OARs) and in healthy brain sparing. The present study aimed to compare 3D-CRT with IMRT to assess tumor volume coverage and OAR sparing for the treatment of malignant gliomas. Materials and methods: We assessed 22 anonymized patients datasets with High Grade Glioblastoma who had undergone post-operative Intensity Modulated Radiotherapy (IMRT) and 3D Conformal Radiotherapy (3D-CRT), This study will compare and contrast treatment plans Rapidarc and 3D-CRT to determine which technology improves significantly dosimetric parameters.
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