Abstract
The induction of micronuclei in cytokinesis-blocked human lymphocytes of different donors has been measured after G 0 irradiation in vitro with a mixed fission neutron-γ-ray beam, 220 kV X-rays and 60Co γ-rays. The dose-response relationships for the micronucleic yeilds were linear-quadratic for both types of low LET radiations. The linear model applied for neutron-induced micronuclei over the dose range 0–0.66 Gy. At higher doses a saturation effect became apparent. For neutron-induced micronucleus yields a limiting RBE value of 12.2 was derived from the ratio of the α coefficients of neutrons and 60Co γ-rays.
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