Dose—response relationship for translocation induction in spermatogonia of the crab-eating monkey ( Macaca fascicularis) by chronic γ-ray-irradiation

Abstract

The induction of reciprocal translocations in spermatogonia of the crab-eating monkey ( Macaca fascicularis) by chronic γ-irradiation (1.8·10 −5 Gy/min, about 0.024 Gy/22 h/day) was examined. The frequencies of translocation per cell were 0.15% at 0.3 Gy, 0.27% at 1.0 Gy and 0.33% at 1.5 Gy. The dose—response relationship for translocation yield was a linear one with a regression coefficient ( b) of 0.16 · 10 −2. When the slope ( b) of the regression line was compared with that at a high dose rate ( (0.25 Gy/min, b = 1.79 · 10 −2), it was clear that the induction rate of translocations after chronic γ-irradiation was only about one-tenth of that after high-dose-rate irradiation. Thus, there was evidence for a pronounced dose-rate effect in the crab-eating monkey.