Dose Volume Parameter Analysis on Late Radiation Induced Pericardial Effusion

Abstract

Purpose/Objective(s)To evaluate the effect of dose-volume parameters on late radiation-induced Pericardial effusion in patients with thoracic carcinoma.Materials/MethodsA total of 49 patients with thoracic neoplasms who received irradiation were involved into the study. All patients underwent echocardiography and chest enhanced CT scan which were used to evaluate late radiation-induced pericardial effusion. Dose-volume parameters were analyzed to explore the influencing factors to it.ResultsDuring the observation period, late radiation-induced pericardial effusion was occurred in 14 patients (28.6%), 12 cases with small amount and 2 cases with middle effusion, there was no large pericardial effusion occurred. The studies showed that V30 and V35 of the heart were higher in late damage group than which in normal group (P=0.035 and P=0.038). Multivariate analysis showed that V30 of the heart was the independent influencing factor to late radiation-induced pericardial effusion (P=0.036). Receiver operator characteristic curve (ROC curve) analysis was used to find the appropriate threshold for V30, the area under ROC curve was 0.695, which meant the accuracy of the prediction was up to medium, the cut-off points were 33.0%. The late radiation-induced pericardial effusion incidence would be increased significantly when the V30 is over 33.0% (43.5% vs 15.4%). V30 prediction of sensitivity and specificity are 71.4%.ConclusionPericardial effusion is the common damage in late radiation-induced heart injury. The occurrence of that is associated with V30 and V35 receiving to the heart, and V30 is the independent influencing factor to late radiation-induced pericardial effusion. However, the final conclusion needs to sample observation. Purpose/Objective(s)To evaluate the effect of dose-volume parameters on late radiation-induced Pericardial effusion in patients with thoracic carcinoma. To evaluate the effect of dose-volume parameters on late radiation-induced Pericardial effusion in patients with thoracic carcinoma. Materials/MethodsA total of 49 patients with thoracic neoplasms who received irradiation were involved into the study. All patients underwent echocardiography and chest enhanced CT scan which were used to evaluate late radiation-induced pericardial effusion. Dose-volume parameters were analyzed to explore the influencing factors to it. A total of 49 patients with thoracic neoplasms who received irradiation were involved into the study. All patients underwent echocardiography and chest enhanced CT scan which were used to evaluate late radiation-induced pericardial effusion. Dose-volume parameters were analyzed to explore the influencing factors to it. ResultsDuring the observation period, late radiation-induced pericardial effusion was occurred in 14 patients (28.6%), 12 cases with small amount and 2 cases with middle effusion, there was no large pericardial effusion occurred. The studies showed that V30 and V35 of the heart were higher in late damage group than which in normal group (P=0.035 and P=0.038). Multivariate analysis showed that V30 of the heart was the independent influencing factor to late radiation-induced pericardial effusion (P=0.036). Receiver operator characteristic curve (ROC curve) analysis was used to find the appropriate threshold for V30, the area under ROC curve was 0.695, which meant the accuracy of the prediction was up to medium, the cut-off points were 33.0%. The late radiation-induced pericardial effusion incidence would be increased significantly when the V30 is over 33.0% (43.5% vs 15.4%). V30 prediction of sensitivity and specificity are 71.4%. During the observation period, late radiation-induced pericardial effusion was occurred in 14 patients (28.6%), 12 cases with small amount and 2 cases with middle effusion, there was no large pericardial effusion occurred. The studies showed that V30 and V35 of the heart were higher in late damage group than which in normal group (P=0.035 and P=0.038). Multivariate analysis showed that V30 of the heart was the independent influencing factor to late radiation-induced pericardial effusion (P=0.036). Receiver operator characteristic curve (ROC curve) analysis was used to find the appropriate threshold for V30, the area under ROC curve was 0.695, which meant the accuracy of the prediction was up to medium, the cut-off points were 33.0%. The late radiation-induced pericardial effusion incidence would be increased significantly when the V30 is over 33.0% (43.5% vs 15.4%). V30 prediction of sensitivity and specificity are 71.4%. ConclusionPericardial effusion is the common damage in late radiation-induced heart injury. The occurrence of that is associated with V30 and V35 receiving to the heart, and V30 is the independent influencing factor to late radiation-induced pericardial effusion. However, the final conclusion needs to sample observation. Pericardial effusion is the common damage in late radiation-induced heart injury. The occurrence of that is associated with V30 and V35 receiving to the heart, and V30 is the independent influencing factor to late radiation-induced pericardial effusion. However, the final conclusion needs to sample observation.