Abstract
The relationship between radiation effect and fraction number was studied in a case of metastatic lung cancer. Three radiotherapeutic fields were taken from multiple pulmonary metastatic foci of squamous-cell carcinoma from the lower jaw. The same total dose was given to each field with the same over-all time, but with three different daily doses. In each radiation field several nodular shadows of metastases were contained, one of which was measured for diameter periodically. Radiation effects were summarized in the formula: log Rn/Ro=(α/t-β)T Where Ro is the tumor size before treatment, Rn is that after irradiation, t the interval of time between fractions, T the over-all time, and α and β constants related to the daily dose.
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