Dose response to ovulation-inducing factor (OIF) in llamas

Abstract

Enteropathy associated with sand accumulation in the large colon of horses has been reported worldwide. Intestinal sand accumulations are commonly treated medically, but randomised controlled clinical trials on horses are scarce. This prospective study evaluated the efficacy of an enterally administered combination of psyllium and magnesium sulphate (MgSO4) for the removal of large colonic sand accumulations in horses without clinical signs of acute colic. The two groups comprised 20 untreated control horses and 20 horses treated with 1 g/kg bodyweight (bwt) of psyllium and 1 g/kg bwt of MgSO4 administered by nasogastric intubation once daily for 4 days.Both groups had no access to soil during the study period. The amounts of accumulated sand were evaluated radiographically before and after treatment. Significantly more treated horses cleared their sand accumulations than horses in the control group. This clearance was determined by observing the estimated quantity by area of sand remaining in the large colon (P < 0.001) and by comparing the numbers of successfully treated horses (P = 0.004) between the two groups after 4 days of treatment. However, there were unexplained individual variations in the clearance of sand accumulation.