Dose-response relationship of sufentanil blunting responses to double-lumen endotracheal intubation when combined with propofol given by TCI in patients with pulmonary tuberculosis

Abstract

Objective To determine the dose-response relationship of sufentanil blunting responses to double-lumen endotracheal intubation when combined with propofol given by target-controlled infusion (TCI) in patients with pulmonary tuberculosis. Methods One hundred patients of both sexes with pulmonary tuberculosis, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, aged 24-58 yr, with body mass index 20% of the baseline value and/or heart rate > 90 bpm within 5 min after intubation.The median effective dose (ED50), ED95 and 95% confidence interval (95% CI) of sufentanil blunting the responses to double-lumen endotracheal intubation were calculated by Probit analysis. Results The ED50 (95% CI) and ED95 (95% CI) of sufentanil blunting the responses to intubation were 0.411 (0.370-0.441) μg/kg and 0.635 (0.556-0.888) μg/kg, respectively, when combined with propofol given by TCI. Conclusion When combined with propofol given by TCI(target plasma concentration 3.5 μg/ml), the ED50 and ED95 of sufentanil blunting the responses to double-lumen endotracheal intubation are 0.411 and 0.635 μg/kg, respectively, in patients with pulmonary tuberculosis. Key words: Propofol; Sufentanil; Dose-response relationship, drug; Tuberculosis, pulmonary; Intubation, intratracheal