Abstract
Objective To determine the relationship between the H-reflex ( H/ M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia. Methods Soleus H-reflexes were serially recorded in 34 subjects (19 men, mean age 32 years, mean follow-up 1.7 years) during simple continuous mode of CITB delivery. Different fitting methods were explored to determine which function best described changes in H/ M ratio with increasing CITB dose. We then calculated effective CITB doses yielding H/ M ratios equal to 75, 50, and 25% (ED 75, ED 50, ED 25) of the baseline recorded before the implant in 22 subjects. Results We found a significant dose–response relationship between the soleus H/ M ratio and CITB dose. A two-decay exponential function was the best fit on each side for pooled data, but a general linear model when controlling for subject. The mean ED 75, ED 50, ED 25 were 30, 70, and 110 mcg/day. Logistical regression predicted with high probability that the H/ M ratio should be less than 30% at CITB doses above 150 mcg/day. Conclusions H/ M ratio is strongly dependent on CITB dose. It sharply decreases up to 150 mcg/day of CITB followed by a plateau. Significance Establishing the relationship between the H/ M ratio and CITB dose may be useful for dose titration and early identification of an ITB system malfunction.
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