Abstract
The T-cell receptor mutant frequency (TCR- Mf) was measured in 53 young adults, who were treated with radioiodine for thyroid cancer. Patients came from the southern part of Belarus. This region had suffered the most from the Chernobyl Disaster. TCR- Mf was determined by flow cytometry before and after 1 to maximal 10 treatments. Before treatment, TCR- Mf of patients was 2.0×10 −4. This Mf value is in the same range as that of young healthy students. After radioiodine therapy (RIT), TCR- Mf increases within about half a year to a maximum. The increase per one mGy to red marrow was 8.7×10 −7. After the maximum TCR- Mf declines exponentially. The half-life of TCR mutants was found to be 3.2 years. On the basis of these data, a calibration curve for the use of TCR- Mf as a biological dosimeter is given.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
