Abstract
Different concentrations of a hot water extract of Desmodium adscendens, a plant used in Ghana to control asthmatic attacks, were used in drinking water to evaluate the plant's anti-anaphylactic properties in guinea pigs. The results show that the extract's inhibition of histamine-induced ileal contraction is largely competitive and that its effect of reducing lung histamine content is dose-dependent. The results also show that the extract causes a dose-dependent reduction in the amount of spasmogens released anaphylactically and in anaphylactic-induced contraction of ilial muscle.
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