Dose-response changes in organ weights and water contents following administration of toxic doses of paracetamol.

Abstract

British Journal of Pharmacology and ChemotherapyVolume 27, Issue 3 p. 497-505 Free Access DOSE-RESPONSE CHANGES IN ORGAN WEIGHTS AND WATER CONTENTS FOLLOWING ADMINISTRATION OF TOXIC DOSES OF PARACETAMOL ELDON M. BOYD, ELDON M. BOYD Department of Pharmacology, Queen's University, Kingston, Ontario, CanadaSearch for more papers by this authorE. PATRICIA SHEPPARD, E. PATRICIA SHEPPARD Department of Pharmacology, Queen's University, Kingston, Ontario, CanadaSearch for more papers by this author ELDON M. BOYD, ELDON M. BOYD Department of Pharmacology, Queen's University, Kingston, Ontario, CanadaSearch for more papers by this authorE. PATRICIA SHEPPARD, E. PATRICIA SHEPPARD Department of Pharmacology, Queen's University, Kingston, Ontario, CanadaSearch for more papers by this author First published: September 1966 https://doi.org/10.1111/j.1476-5381.1966.tb01862.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES Boyd, E. M. & Abel, M. (1966). The acute toxicity of barium sulfate administered intragastrically. Can. med. Ass. J., 94, 849– 853. Boyd, E. M. & Bereczky, G. M. (1966). Liver necrosis from paracetamol. Br. J. Pharmac. Chemother., 26, 606– 614. Boyd, E. M., Fulford, R. A. & Harris, R. D. (1961). Prediction of the lethal dose of benzylpenicillin and acetylsalicylic acid. Toxic, appl. Pharmac., 3, 402– 410. Boyd, E. M. & Knight, L. M. (1963). Postmortem shifts in the weight and water levels of body organs. Toxic, appl. Pharmac., 5, 119– 128. Boyd, E. M. & Lloyd, G. R. (1965). Minimal oral doses of benzylpenicillin producing signs of toxicity in albino rats. Archs int. Pharmacodyn. Thar., 156, 172– 179. Canada (1965). Office Consolidation of the Food and Drugs Act and of the Food and Drug Regulations with Amendments to September 3, 1964, pp. 126B– 126F. Ottawa: Department of National Health and Welfare, Queen's Printer and Controller of Stationery. Committee on Safety of Drugs (1963). Notes for the Guidance of Manufacturers Submitting Information on Toxicity Tests, p. 2. London: Committee on Safety of Drugs. Committee on Safety of Drugs (1965). Memorandum to Manufacturers and Other Persons Developing or Proposing to Market a Drug in the United Kingdom, p. 3. London: Committee on Safety of Drugs. Croxton, F. E. (1953). Elementary Statistics with Applications in Medicine. New York: Prentice-Hall. Dunlop, D. (1965). Use and abuse of drugs. Br. med. J., 2, 437– 441. Expert Committee on Drug Toxicity (1964). First Report of the Expert Committee on Drug Toxicity, p. 9. (Chairman: R. S. S. Hennessey.) London: Association of the British Pharmaceutical Industry. Food and Drug Directorate (1965). Guide for Completing Preclinical Submissions on Investigational Drugs, p. 8. Ottawa: Department of National Health and Welfare. United States of America (1963). New Drug Regulations under the Federal Food, Drug, and Cosmetic Act, Revised June 20, 1963, p. 3. Washington: U.S. Department of Health, Education, and Welfare, Food and Drug Administration. Citing Literature Volume27, Issue3September 1966Pages 497-505 ReferencesRelatedInformation