Abstract
Chlorogenic acids are coffee bioactives that are becoming of great interest for their health promoting effects. However, human bioavailability of these compounds is not fully understood. We investigated dose response plasma appearance of coffee chlorogenic (CGAs) and phenolic (PAs) acids after ingestion of increasing doses of soluble coffee by 10 healthy volunteers.Two groups of metabolites appeared over 24h where plasma CGAs and PAs were measured after enzymatic treatment. The first group of metabolites appeared rapidly, less than 2 hours after ingestion, indicative of intestinal absorption. Dihydrocaffeic and dihydroferulic acids peaked around 10h, which suggest colonic metabolism and absorption. Regardless of the dose, colonic metabolites were the most present compounds, followed by phenolic acids and chlorogenic acids. Finally, all compounds quantified in plasma showed a positive dose response effect proportional to the ingested dose, indicating passive absorption mechanisms. It also highlights the importance of this beverage as a significant dietary source of bioavailable bioactive compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
