Abstract
The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine. 108 patients of ASA I and II, aged 18 to 65 years undergoing lower abdominal surgeries under spinal anaesthesia were randomized into three groups.. Control group A (n=36) no oral clonidine pre-medication, Group B (n=36) and group C (n=36) received 100 µg and 200 µg of oral clonidine pre-medication respectively, 1hr before spinal anaesthesia. Haemodynamic parameters were recorded. Sensory block, degree of motor blockage, and sedation were assessed. Clonidine prolonged the mean duration of motor block by 189.98±26.93 min (100µg) and 191.89±28.13 min (200µg) compared to 117.92±25.13 min in the control group p<0.05. The mean duration of analgesia was 188.19±35 min (100µg) and194±24.58 min (200µg) in the clonidine groups compared to 115.89±26.66 min in control group p<0.05. All the patients were awake in the control group while 71.43% and 100% were drowsy in groups B and C respectively. Oral clonidine produces better clinical effects on the onset and duration of Bupivacaine spinal anaesthesia.
Highlights
The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine
There were no significant differences in the variables between the three groups at rest before oral clonidine was given
There were no differences in the duration of sensory and motor blocks between the two clonidine groups in this study. Comparing these results with those of Ota et al12,who concluded that the effect of oral clonidine on duration of tetracaine spinal anaesthesia seems to plateau at 150μg, this study shows that the effect of oral clonidine on duration of sensory and motor block in bupivacaine spinal anaesthesia is in the dose range of 100-200μg
Summary
The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine. Results: Clonidine prolonged the mean duration of motor block by 189.98±26.93 min (100μg) and 191.89±28.13 min (200μg) compared to 117.92±25.13 min in the control group p
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