Abstract
Dose-Related Effects of Melatonin on Human Osteoblastic Cells via in vitro Controlled Release from Nanoscale Calcium Sulfate
Highlights
Engineering biodegradable scaffolds for bone regeneration in osseous defects is an attractive alternative to harvesting grafts from living tissues
Exposure of human osteoblastic cells to melatonin at micromolar concentrations increased cellular viability and alkaline phosphatase activity
Incorporation of melatonin into nanoscale calcium sulfate increased the viability of cells seeded with the scaffolds
Summary
Engineering biodegradable scaffolds for bone regeneration in osseous defects is an attractive alternative to harvesting grafts from living tissues. Its clinical efficacy though may be limited by dose-related variation in its stimulatory effects on bone cells To these ends, the incorporation of melatonin into nanoscale calcium sulfate may give rise to a novel scaffolding system the potential for clinical application in bone regenerative medicine. In hopes of circumventing some of the characteristic limitations associated with grafts harvested from living tissues, a vast number of FDA approved bone graft substitutes have emerged on the market in recent decades [13]. Most of these synthetic constructs are hard, yet brittle, and lack intrinsic osteoinductive and osteogenic properties, are only osteoconductive [1]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Dentistry and Oral Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
