Dose-dependent improvement of gas exchange by intratracheal perflubron (perfluorooctylbromide) instillation in adult animals with acute respiratory failure.

Abstract

Liquid ventilation with oxygenated perfluorocarbons (PFC) has been shown to improve pulmonary gas exchange and lung mechanics in preterm animals with respiratory failure [1–4]. Histological studies also reveal that liquid ventilation is less harmful to the lung structures than conventional gas ventilation [3,5]. Moreover, the first human application of liquid ventilation has been reported with promising success in premature infants with severe respiratory distress in whom conventional therapies had failed [6].KeywordsAcute Respiratory FailureLung MechanicIntratracheal InstillationLung LavageSevere Respiratory DistressThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.