Dose Dependent Efficacy of Lacosamide in Protection of Pentylenetetrazol Induced Seizure in Rats

Abstract

Epilepsy is a common and frequently devastated disorder affecting 0.5 to 1% of the population with annual incidence rate of approximately 30 to 50 per 1, 00,000 per year. Lacosamide is a novel anti-epileptic drug, recently been licensed for adjunctive therapy of partial or secondary generalized seizures. Objective: To evaluate dose dependent efficacy of lacosamide in protection of Pentylenetetrazol (PTZ) induced seizures in rats. Method: The study was conducted in albino rats of either sex, weighing between 100-150 gm. The animals were grouped into 6 groups, each compromised of 8 animals. Group I was treated with requisite volume of normal saline, group II received pentylenetetrazol (80mg/kg, i.p). Animals in group III, IV,V and VI were pretreated with graded doses of lacosamide (3,10,30& 50mg/kg i.p),thirty minutes later, the lacosamide pretreated groups were treated with pentylenetetrazol (80mg/kg/i.p). Results: It was found that animals in control group were normal, while the animals with PTZ treatment showed convulsions followed by mortality. However in group III 38%, group IV 60%, group V 88% & group VI 100% protection was observed with lacosamide against PTZ induced seizures. Conclusion: So, in our study we observed that in the doses of 30 and 50mg/kg, ip, lacosamide increased the seizure threshold and showed protection against the minimal seizure.