Abstract
Vitamin C is a part of cell physiology and is utilized in many metabolic reactions. Therapeutically, it was found useful in many ailments including fatal diseases such as cancer. It has ability to induce apoptotic pathway in cancer cells in order to kill them within the body at lower concentrations without affecting the non-cancerous cells.
Highlights
Vitamin C, known as ascorbate or ascorbic acid, is an essential water-soluble vitamin required for several physiological mechanisms in plant and animal cells
Vitamin C was proved to be helpful for cancer cells in creation of resistance in them against chemotherapeutic drugs. This notion was confirmed by a study conducted on human colon cancer cells and Vitamin C blocks drug-mediated apoptosis induction allowing cancer cells to become insensitive to chemotherapeutics [3]
Vitamin C combined with arginine to treat different cancer cell lines which proved much cytotoxic as compared to non-cancerous human cells [2]
Summary
Vitamin C, known as ascorbate or ascorbic acid, is an essential water-soluble vitamin required for several physiological mechanisms in plant and animal cells. Vitamin C has been shown to induce cancer cell death at concentration of 20 mM in various cancer cell lines [17]. Low doses of Vitamin C can display antioxidant property and prevent initiation of oxidant-induced apoptosis. Vitamin C has been proved as a pro-oxidant agent at pharmacological concentrations in different cancer studies.
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