Abstract
The effects of testosterone propionate (TP) on food intake and body weight were investigated using adult male Sprague-Dawley rats. Daily injections of a high (1 mg) or a low (0.2 mg) dose of TP were administered for 8 weeks beginning immediately after castration. Both doses of TP reduced body weight gain during the first 4 weeks of treatment, but long-term treatment with the low dose stimulated food intake and body weight gain. Injections of the high dose of TP reduced body weight gain and food intake over the 8 weeks of treatment. These findings suggest that the effects of TP on body weight and feeding are dose dependent. Considering previous data, a maintenance paradigm of hormone replacement seems to maximize the anorexic and weight-reducing effects of TP treatment.
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