Abstract

Although the platelet active agents that show promise as clinically effective antithrombotic drugs have effects on platelet function that are dose related, there is little information available from controlled clinical trials of the effect of different drug doses on thrombosis in man. Even among the agents whose therapeutic efficacy has been established by prospective controlled clinical trials, there are few data regarding the effect of different doses on thrombosis, and most of our present working knowledge is derived from studies of parallel phenomena, such as platelet survival, platelet aggregation, and similar processes whose relation to thrombosis is not always clear.

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