Abstract
The frequency of chromosomal aberrations in bone marrow cells, after a single i.p. aflatoxin B 1 (AFB 1) dose, was examined in male Chinese hamsters ( Cricetulus griseus). There was a significant increase in aberrant cells within 5 days of administration of a dose of 0.1 μg-5 mg AFB 1/kg, and on the 36th day. After a single dose of 5 mg AFB 1/kg the enhanced frequency of aberrant cells was monitored up to day 104 with no sign of a decrease to control level. The results indicate that the minimum mutagenic effect of an AFB 1 dose in this system is 0.1 μg/kg. Attention is drawn to the long-term presence of chromosomal aberrations even after a single i.p. exposure to AFB 1
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