Dose and duration dependent toxicity of Dioxin (2,3,7,8 TCDD) to few lysosomal enzymes in mice kidney

Abstract

TCDD, a highly toxic lipophilic Dioxin, causes many health problems in animals including human when exposed through dietary intake of fat. Present communication reports in vivo dose and exposure duration dependent cellular toxicity of environmentally available concentration of TCDD to few lysosomal enzymes in mice kidney. The study tests two hypotheses (a) environmentally available low concentration of TCDD provokes dose and exposure duration dependent toxic effects to lysosomal enzymes and, (b) Low dose TCDD exposure may trigger cellular apoptosis by altering different lysosomal enzymes. Groups of female Swiss albino mice were subjected to different concentration of TCDD (0.004 mg/kg bw/d, 0.04 mg/kg bw/d) by oral gavage for 2,4 and 6 days of exposure duration. The observed results suggested that significantly dose and exposure duration dependent effects were found in kidney cells of mice. The results indicate TCDD possibly causing oxidative stress and disturb cell homeostasis by increasing intracellular ions. ROS and increased ions may be responsible for the alteration of different physiological activity of cell. Though the exact process is not clear at present, but it is also possible that altered functions of key lysosomal enzymes might have evoked the process of cell destruction and cell apoptosis.