Abstract
There is at times marked variability in drug responsiveness especially in critically ill patients admitted in the Intensive care units. In order to obtain therapeutic effectiveness with in pharmacokinetic parameters related to therapeutic dose, it is always desirable to monitor and to maintain drug dose adjustment in such a way especially in presence of organ failure like renal failure, hepatic failure or any other clinical situation necessitating Therapeutic Drug Monitoring (TDM) so that one can use safe and effective drug therapy with least toxicity due to inaccurate and invalid drug doses. Keywords : Drug, Dose adjustment, Patient's care, Adverse drug reaction. Internet Journal of Medical Update Vol. 1 (1) 2006: pp. 19-23
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