Dosages des IgG antiaviaires et antimoisissures sur UniCAP dans l'alvéolite allergique extrinsèque et l'aspergillose bronchopulmonaire allergique

Abstract

Immunofluorimetric determination of IgG specific antibodies may be realised with UniCAP system (Pharmacia). We have measured IgG titers against birds (budgerigar, parrot, pigeon, canary) , thermophilic actinomycetes (Thermoactinomyces vulgaris, Micropolyspora faeni) and molds (Aspergillus fumigatus and vulgaris, Penecillium sp, Cladosporium herbarum and cladosporoïdes, Stachybotrys atra, Alternaria tenuis) in 12 patients with clinically proven hypersensitivity pneumonitis. We observed elevated IgG in 83% of the subjects using normal values established in our laboratory. On the contrary, in 15 patients for whom diagnostic was only suspected, IgG where normal or not significanty elevated. Mold IgG antibodies interest is limited to inacurate choice of the antigen rather than to the absence of disease. The results must always be interpreted in accordance with clinic. Anti-Aspergillus fumigatus antibodies where realised in 43 patients with asthma or cystic fibrosis. Among six patients with clinical proven allergic bronchopulmonary aspergillosis, only 3 had high IgG titers. Despite of those false negative results, measurement of IgG especially againts birds and Aspergillus fumigatus is an useful diagnostic tool in the diagnosis of pneumopathy caused by fungi or birds.