Abstract
Tablet granulations of phenobarbetal and reserpine were prepared on a routine manufacturing basis and compressed on a single-punch tablet press. The tablets were collected in small groups in the order of compression, weighed, and analyzed individually. Statistical quality control charts were prepared for weight variation and per cent composition, the main variables affecting the dosage variation. Inspection of the control charts and results obtained by application of the F-test indicated that some disruption of uniformity occurred during the compression of the tablets.
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