Abstract
SUMMARY The plasma concentrations reached following the epidural injection of 200, 400, 500, 600 and 700 mg of lignocaine have been determined. From these results, a linear relationship between dosage and plasma concentration was established. Plasma concentrations following rapid injection (400 mg in 15 seconds) were determined and found to be slightly higher than slower (60 seconds) injection. Statistical analysis of data has allowed a preliminary evaluation of the effects of weight and age upon the plasma concentrations of lignocaine. Recommendations on the dosage of lignocaine in epidural block in regard to toxicity are made, and the effects of the various factors affecting the absorption and elimination of local anaesthetic agents are assessed.
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