Abstract
A new method is presented for preparing dosage forms capable of delivering drug at a controlled rate. They are prepared by dispersing in a polymeric matrix such as Eudragit, a polymer to which the drug is attached. The branched polymer is obtained by polymerizing a monomer previously attached to the drug by a covalent bond. The anhydride function was chosen for branching the salicylic acid, since it reacts readily with water. The pharmaceutical dosage forms obtained, release the drug when contacted with aqueous solutions of various pH values, ranging from 1 to 8. The transfer of drug is controlled by transient diffusion with a constant diffusivity, as well as the transfer of the liquid throughout the dosage form. A simple model was successfully tested for the release of the drug.
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