Dorsomedial striatum, but not dorsolateral striatum, is necessary for rat category learning.

Abstract

Categorization is an adaptive cognitive function that allows us to generalize knowledge to novel situations. Converging evidence from neuropsychological, neuroimaging, and neurophysiological studies suggest that categorization is mediated by the basal ganglia; however, there is debate regarding the necessity of each subregion of the basal ganglia and their respective functions. The current experiment examined the roles of the dorsomedial striatum (DMS; homologous to the head of the caudate nucleus) and dorsolateral striatum (DLS; homologous to the body and tail of the caudate nucleus) in category learning by combining selective lesions with computational modeling. Using a touchscreen apparatus, rats were trained to categorize distributions of visual stimuli that varied along two continuous dimensions (i.e., spatial frequency and orientation). The tasks either required attention to one stimulus dimension (spatial frequency or orientation; 1D tasks) or both stimulus dimensions (spatial frequency and orientation; 2D tasks). Rats with NMDA lesions of the DMS were impaired on both the 1D tasks and 2D tasks, whereas rats with DLS lesions showed no impairments. The lesions did not affect performance on a discrimination task that had the same trial structure as the categorization tasks, suggesting that the category impairments effected processes relevant to categorization. Model simulations were conducted using a neural network to assess the effect of the DMS lesions on category learning. Together, the results suggest that the DMS is critical to map category representations to appropriate behavioral responses, whereas the DLS is not necessary for categorization.