Dorsolateral Prefrontal Cortex Single Nuclei Tensor Decomposition Identifies Shared Genetic Risk for Major Depressive Disorder and Schizophrenia in Suicidal Subjects

Abstract

Previous reports on brain co-expression networks have assigned genes to unique co-expression gene sets using cluster-based strategies. This feature is incompatible with the diversity of cell populations involved. We investigated gene co-expression in single nuclei RNA-sequencing from the dorsolateral prefrontal cortex of patients with Major Depressive Disorder (MDD) and neurotypical controls (NC) using Tensor Models to identify components with overlapping gene memberships. We associated co-expression components with diagnosis and risk for psychiatric disorders.