Abstract
Objective This study explored the clinical application value of image denoising algorithm combined with Doppler ultrasound imaging in evaluation of aspirin combined with low-molecular-weight heparin (LMWH) on fetal growth restriction (FGR). Method A two-stage image denoising by principal component analysis (PCA) with local pixel grouping (LPG-PCA) denoising algorithm was constructed in this study. Eighty FGR pregnant women were included in the study, and they were rolled into an experimental group (aspirin enteric-coated tablets + LMWH calcium injection) and a control group (LMWH calcium injection) according to the different treatment plans, with 40 cases in each group. All patients were performed with Doppler ultrasound imaging. The blood flow parameters (BFPs) were recorded and compared before and after the treatment in two groups, including power index (PI), resistance index (RI), high systolic blood flow velocity (S), high diastolic blood flow velocity (D), S/D value, and peak systolic velocity (PSV). In addition, the middle cerebral artery (MCA) BFPs, cerebral placental rate (CPR), amniotic fluid index (AFI) and perinatal outcome (PO) of the two groups were compared. Results The total effective rate of treatment in group A (87.5%) was greatly higher than that in group B (62.5%), showing statistical difference (P < 0.05). The PI (0.72 ± 0.19), RI (0.57 ± 0.17), and S/D values (2.26 ± 0.43) in group A were dramatically lower than those in group B, which were 0.92 ± 0.21, 0.75 ± 0.14, and 2.64 ± 0.45, respectively (P < 0.05), and the AFI was higher (13.71 ± 2.2 cm vs 11.38 ± 2.16 cm) (P < 0.05). The Apgar score (9.17 ± 0.26), weight (3.57 ± 1.08), and gestational age (38.85 ± 2.50) of group A were all higher in contrast to those of group B, which were 7.33 ± 0.25, 2.61 ± 1.13, and 36.18 ± 2.25, respectively (P < 0.05). In addition, the fetal double parietal diameter (2.4 ± 0.9 mm), femur diameter (2.2 ± 0.6 mm), head circumference (1.2 ± 0.4 mm), abdominal circumference (1.3 ± 0.7 mm), and uterine height (0.8 ± 0.3 mm) in group A were obviously superior to those in group B, which were 1.8 ± 0.4 mm, 1.7 ± 0.5 mm, 0.8 ± 0.2 mm, 0.9 ± 0.4 mm, and 0.4 ± 0.6 mm, respectively, showing statistically observable differences (P < 0.05). Conclusion Doppler ultrasound based on image denoising algorithm can accurately evaluate the effect of aspirin combined with LMWH on the improvement of FGR and showed good application value.
Highlights
Fetal growth restriction (FGR) is defined as a child whose fetus is unable to achieve its intended growth potential and is small for its gestational age, and it is a relatively common disease in obstetrics [1]
A two-stage image denoising by principal component analysis (PCA) with local pixel grouping (LPG-PCA) denoising algorithm was constructed in this study
Studies have found that the blood of FGR pregnant women is in a state of hypercoagulability [3,4], so improving the hypercoagulable state of pregnant women and placental blood perfusion is the key to the treatment of FGR [5]. erefore, timely and effective treatment of FGR is the key to improving the prognosis of perinatal infants
Summary
Fetal growth restriction (FGR) is defined as a child whose fetus is unable to achieve its intended growth potential and is small for its gestational age (birth weight is less than the 10th percentile below the weight of the same age), and it is a relatively common disease in obstetrics [1]. Studies have found that the blood of FGR pregnant women is in a state of hypercoagulability [3,4], so improving the hypercoagulable state of pregnant women and placental blood perfusion is the key to the treatment of FGR [5]. Low-molecular-weight heparin (LMWH) has a certain effect in the treatment of FGR. It has effects on improving uterine placental blood circulation, reducing blood viscosity, and enhancing placental blood supply [6,7], but monotherapy is still insufficient. Related studies have found that aspirin can improve placental function, improve clinical pregnancy rate, and reduce the incidence of recurrent miscarriage [8]
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