Doppler perfusion index in adolescents with non-alcoholic fatty liver disease

Maryam Riahinezhad,Shafigheh Parsai Arshad,Maryam Farghadani,Hossein Saneian

doi:10.34172/ipp.2021.07

Maryam Riahinezhad, Shafigheh Parsai Arshad + Show 2 more

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https://doi.org/10.34172/ipp.2021.07

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Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) as a multi-factorial disorder is the most common cause of abnormal liver function tests in adolescents. Objectives: The present study aimed to assess Doppler perfusion index (DPI) in adolescents with NAFLD as compared with healthy subjects. Patients and Methods: Thirty-seven adolescents with NAFLD and 25 healthy individuals were enrolled in the study. Hemodynamic indices were measured using a color Doppler ultrasound machine. Severity of fatty liver disease and steatosis grade were assessed using FibroScan. The measured indices were peak systolic velocity (PSV), resistive index (RI), end-diastolic velocity (EDV), time-averaged mean velocity (TAMV), time-averaged peak velocity (TAPV), portal venous blood flow (PVBF) volume, hepatic arterial blood flow (HABF) volume, and DPI. Results: The mean of DPI in the case and control groups was 0.31±0.11 and 0.31±0.09, respectively (P=0.972). HABF volume was significantly lower in the case group as compared with the control group (103.8 versus 153.3 respectively, P=0.015). PSV, TAMV, mean velocity, and PVBF volume were significantly lower in the case group as compared with the control group (P<0.05). Patients with a higher steatosis grade indicated a significantly lower mean of PSV and TAMV portal than controls (P<0.05). Conclusion: DPI was similar in adolescents with NAFLD and healthy subjects and was not associated with severity of fatty liver disease and steatosis grade. In addition, the percentage of steatosis would be increased with increased liver span.

Highlights

Non-alcoholic fatty liver disease (NAFLD) as a multi-factorial disorder is the most common cause of abnormal liver function tests in adolescents
NAFLD is a multifactorial disorder closely associated with the metabolic syndrome and refers to a spectrum of diseases ranging from steatosis to steatohepatitis, fibrosis, and eventually cirrhosis [2]
The present study examined 37 adolescents with nonalcoholic fatty liver disease (NAFLD) and 25 healthy individuals and revealed that Doppler perfusion index (DPI) was not different between healthy adolescents and those with NAFLD

Summary

Introduction

Non-alcoholic fatty liver disease (NAFLD) as a multi-factorial disorder is the most common cause of abnormal liver function tests in adolescents. Objectives: The present study aimed to assess Doppler perfusion index (DPI) in adolescents with NAFLD as compared with healthy subjects. Severity of fatty liver disease and steatosis grade were assessed using FibroScan. HABF volume was significantly lower in the case group as compared with the control group (103.8 versus 153.3 respectively, P = 0.015). PSV, TAMV, mean velocity, and PVBF volume were significantly lower in the case group as compared with the control group (P < 0.05). Patients with a higher steatosis grade indicated a significantly lower mean of PSV and TAMV portal than controls (P < 0.05). Conclusion: DPI was similar in adolescents with NAFLD and healthy subjects and was not associated with severity of fatty liver disease and steatosis grade. The increasing prevalence rates of childhood obesity and metabolic syndrome make

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