Doping Dopamine in Carbon Nanoparticles: A New Multifunctional Logic-Based Decision-Making Molecule.

Abstract

A dopamine-functionalized carbon nanoparticle (CNP)-based platform is designed to reversibly control the optical signal, leading to a multifunctional logic system regulated by pH and light. pH-regulated unique reversible transformation of oxidized and reduced forms of a neurotransmitter, dopamine, conjugated with CNPs plays a decisive role in capturing the final output of the logic function. Inspired by this phenomenon, herein, we report the use of dopamine-docked CNPs to construct different molecular logic gates with an intention to develop the next-generation molecular logic gates. We could successfully construct two basic molecular logic gates, namely, YES and NOT, using one input; two modular logic gates; an IMPLICATION logic gate using two inputs; and finally a combination of OR and AND gates using three inputs. The optical response of the synthesized NP conjugate provides a fluorescence-based "Erase-Read-Write-Read" function. The proposed phenomenon may open a new concept of biochemical logic gates with fluorescence output for neuronal imaging.