Abstract
This study examines the mechanism of dopaminergic modulation of aldosterone secretion in normal man. Nine normal male volunteers in metabolic balance at 100 meq sodium/ day and 60 meq potassium/day constant intake received metoclopramide (10 mg iv) with 5% dextrose (vehicle), with dopamine (3 eg/kg-min, with saralasin (10 eg/kg-min), or after 4 days of dexamethasone (2 mg orally every 6 h) or placebo. Metoclopramide in the presence of vehicle increased plasma aldosterone concentrations from 12.5 ± 1.2 to a maximum of 25.0 ± 2.5 ng/dl (P < 0.01) and serum PRL concentrations from 10.0 ± 1.1 to a maximum of 74.9 ± 8.6 ng/ml. The aldosterone and PRL responses displayed a parallel time course, with significant responses of both occurring 5 min after metoclopramide administration. A significant rise (P < 0.05) in plasma renin activity (PRA) from 2.7 ± 0.4 ng/ml h−1 to 4.5 ± 1.0 ng/ml h−1 was observed only at the 30-min sampling time. Dopamine infusion suppressed the aldosterone, PRL, and PRA responses to metocl...
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