Abstract
Tyrosine hydroxylase immunohistochemical analysis of the dorsal raphe nucleus (DRN) of severely parkinsonian MPTP-treated cats and cynomolgus monkeys revealed a marked loss of catecholaminergic neurons in this region. Cell loss was more extensive in the ventral portion of the nucleus with a relative sparing of neurons in the dorsal-most portions of the DRN. These results demonstrate that catecholaminergic neurons other than those in the ventral mesencephalon and the locus ceruleus are affected by the toxic effects of MPTP.
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