Abstract
Dopamine transporter density of striatum showed to be increased in Schizophrenia first-episode drug-naïve patients
Highlights
Schizophrenia, from the Greek roots skizo (“I split”) and phren (“mind”) is a chronic CNS disease characterized by impairment of thought process, affection, behaviour and perception
We evaluated pre-synaptic dopamine transporter density with single photon emission computed tomography (SPECT) using 123I-FP-CIT (DaT Scan) and regional cerebral blood flow rCBF using HMPAO in first episode drug-naive patients suffering from schizophrenia
In DaT Scan the visually analysis of the images was interpreted as a normal image but the semiquantitave analysis of the images showed an increase in mean uptake of the radiotracer in striatum(p=0.00), caudate nuclei (p=0.00) and putamen (p=0.00) of patients with schizophrenia in comparison with control group (Figure 2)
Summary
Schizophrenia, from the Greek roots skizo (“I split”) and phren (“mind”) is a chronic CNS disease characterized by impairment of thought process, affection, behaviour and perception. The effectiveness of schizophrenia treatment is often assessed using standardized methods, one of the most common is the Positive and Negative Syndrome Scale (PANSS). The PANSS is a 30-item scale, which includes a 7-item positive scale, a 7-item negative scale, and a 16-item general psychopathology scale which includes ratings of mood problems. The PANSS is validated for schizophrenia and is based on patient and carers interview. Treatment with dopamine-antagonists suggests that dopamine plays an important role in the pathophysiology of schizophrenia [5,6]. Successful treatment with dopamine antagonists plays a crucial role of the neurotransmitter dopamine in the pathophysiology of schizophrenia. About the dopaminergic function in schizophrenia and there is a controversy among different studies
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