Abstract
Derivation of dopaminergic neurons from patients' induced pluripotent stem-cells (iPSCs) can enhance our understanding of the biology of dopamine-related illnesses, such as schizophrenia and Parkinson disease (PD), and provide transformative information for biological psychiatry research. However, whether dopaminergic properties of these neurons capture interindividual variation in central dopamine functioning is unknown. [18F]-FDOPA PET measures presynaptic dopamine synthesis capacity and vesicular storage, identifying hallmark diminished striatal dopaminergic content in idiopathic PD. Since mutations in GBA1, the gene implicated in Gaucher disease (GD), are an important risk factor for parkinsonism, we evaluated individuals with both GD and a family history of PD, testing for correspondence between dopamine-related measurements from both iPSC-derived neurons and molecular neuroimaging of the living brain.
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