Abstract
1. Of several putative transmitters used, dopamine was the only one which caused (at low concentrations) a hyperpolarizing response (H-response) in growth hormone producing cells (GHCs) of the freshwater snail Lynmaea stagnalis. 2. Membrane resistance changes, and shifts in the reversal potential of this H-response in different K +-concentrations, indicate that the response is due to an increase in potassium conductance. 3. The dopamine induced H-response is blocked by (−)-sulpiride, 4-aminopyridine. dibutyryl cAMP. 8CPT-cAMP, forskolin and IBMX. 4. These data suggest that dopamine induces the H-response by stimulating a receptor resembling the mammalian D-2 receptor and that this effect of dopamine is mediated by a decrease in the formation of intracellular cAMP.
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