Abstract
Dopamine receptor partial agonists (DRPAs; aripiprazole, brexpiprazole, and cariprazine) constitute a novel class of antipsychotics. Although they share a similar mechanism of action, DRPAs differ in their pharmacodynamics, pharmacokinetics, drug interactions, or safety and tolerability. The antipsychotic efficacy of all three drugs was established in several placebo-controlled randomized trials (RCTs) in schizophrenia, both acute phase and relapse prevention. In addition, each of the DRPA agents has been tested in other psychiatric disorders, including bipolar disorder or major depression. However, a few studies have examined their comparative clinical efficacy. There are no head-to-head comparisons between aripiprazole, brexpiprazole, or cariprazine. In two acute schizophrenia RCTs of cariprazine and brexpiprazole, aripiprazole was used as an indirect comparator to control for study sensitivity. To assess potential differences in the efficacy of DRPAs, we reviewed data from controlled trials, systematic reviews, and meta-analyses. Our results showed that the acute antipsychotic effects of DRPAs, as measured by the number needed to treat, are comparable. The three agents were superior to placebo in acute treatment, and cariprazine was found to be effective in the reduction of primary negative symptoms of schizophrenia. In the therapy of bipolar disorder, aripiprazole and cariprazine showed antimanic efficacy, cariprazine was also effective in the management of bipolar depression, and aripiprazole was effective for relapse prevention. The addon administration of aripiprazole or brexpiprazole reduced symptoms of major depression. Aripiprazole can control acute agitation associated with psychosis or bipolar disorder; brexpiprazole showed the potential to manage agitation in dementia patients. Aripiprazole has also established evidence of efficacy in children and adolescents and other conditions: OCD, tic disorders, and autism spectrum disorder. Our review of published data suggests that in terms of clinical efficacy, DRPAs are a heterogeneous group, with each drug possessing its own therapeutic benefits.
Highlights
Antipsychotic drugs represent the mainstay of schizophrenia treatment [1]
The therapeutic efficacy of aripiprazole, brexpiprazole, and cariprazine was tested in 68 randomized controlled trials (RCTs) with schizophrenia (Table 2), 26 RCTs with bipolar disorder, 19 RCTs with major depression (Table 3), and 30 RCTs in other neuropsychiatric disorders (Table 4)
The oral formulation of aripiprazole was significantly more efficacious than placebo in the overall change of symptoms (n = 1,926 patients; standardized mean difference (SMD) = −0.41, 95% CI −0.50, −0.32), positive symptoms (n = 1,451; SMD = −0.38, 95% CI −0.48, −0.28), negative symptoms (n = 1,353; SMD = −0.33, 95% CI −0.41, −0.24), and depressive symptoms (n = 150; SMD = −0.40, 95% CI −0.69, −0.10), but not in social functioning (n = 50; SMD = −0.23, 95% CI −0.55, 0.09)
Summary
Antipsychotic drugs represent the mainstay of schizophrenia treatment [1]. They all share a common mechanism of action: antagonism at postsynaptic dopamine D2 receptors [2]. Three DRPAs have been approved for clinical use: aripiprazole, brexpiprazole, and cariprazine. Comparing their pharmacodynamics, aripiprazole has the highest intrinsic D2 activity, and cariprazine has the highest D3 activity (Table 1) [4, 5]. Brexpiprazole with a lower intrinsic D2 and D3 has less activating effects and lower risk for akathisia, insomnia, nausea, and dyspepsia
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
