Dopamine, Opioids, and Positron Emission Tomography Imaging of the Human Brain: Contrasting Findings in Opioid Use Disorder and Healthy Volunteers

Abstract

SEE CORRESPONDING ARTICLE ON PAGE 356 Striatal Dopamine Release in Response to Morphine: A [11C]Raclopride Positron Emission Tomography Study in Healthy MenBiological PsychiatryVol. 86Issue 5PreviewPreclinical and human positron emission tomography studies have produced inconsistent results regarding the effects of opioids on mesolimbic dopamine (DA). Here, we quantify striatal DA release (measured by [11C]raclopride displacement) in response to an intravenous infusion of morphine, and its relationship with morphine-induced subjective effects, in healthy, nondependent opioid–experienced participants. Full-Text PDF