Abstract
The mechanisms subserving the behavioral effects of the putatively selective dopamine D 2 agonist LY 171555 (0.025 mg/kg) were analyzed in rats (N = 23 using a two-lever, water-reinforced drug discrimination task. Substitution (generalization) tests showed that the DA agonist apomorphine mimicked LY 171555 while the selective D 1 agonist SKF 38393 did not. When given in combination with the training drug, haloperidol but not the D 1 antagonist Sch 23390 dose dependently blocked the LY 171555 cue; given alone, Sch 23390 mimicked LY 171555 and haloperidol elicited responding on the saline-appropriate lever. These results suggest that stimulus properties of LY 171555 are mediated primarily by D 2-containing neuronal systems but that the effects of stimulating either D 1 or D 2 receptor subtypes in vivo are complex and interdependent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
