Abstract
A conformational analysis has been made of the structures of trans- and cis- octahydrobenzo[f]quinoline systems, and this stereochemistry has been related to that of proposed biologically significant conformers of dopamine and of 2-aminodihydroxytetralins. A trans -N-n-propyl octahydrobenzo[f]quinoline exhibited unusually high dopaminergic activity. The potentiating effect of the N-n-propyl group in many dopaminergic molecules is described and discussed. Structures of the biologically active subject compounds have been compared with the structures of ergoline derivatives and of benzo[a]phenanthridine systems.
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