Dopamine-based mechanism for transient forgetting.

Abstract

Active forgetting is an essential component of the brain’s memory management system1. Forgetting can be permanent, in which prior memory is lost completely; or transient, in which memory exists in a temporary state of impaired retrieval. Such temporary blocks on memory seem universal, and can disrupt an individual’s plans, social interactions, and ability to make rapid, flexible and appropriate choices. However, the neurobiological mechanisms that cause transient forgetting are unknown. Here we identify a single dopamine neuron in Drosophila that mediates memory suppression resulting in transient forgetting. Artificially activating this neuron failed to abolish the expression of long-term memory. Rather, it briefly suppressed memory retrieval, with memory becoming accessible with time. The dopamine neuron modulates memory retrieval by stimulating a unique dopamine receptor expressed in a restricted physical compartment of the axons of mushroom body neurons. This mechanism for transient forgetting is triggered by interfering stimuli presented just prior to retrieval.