Abstract
Publisher Summary This chapter describes the effect of neuroleptic drugs on dopamine (DA) and acetylcholine (ACh) neurons in striatal and limbic structures. Involvement of DA in schizophrenic states is suggested by several observations but mainly by the fact that neuroleptic drugs block DA receptors, whereas structurally related compounds devoid of such an effect do not show therapeutic activity. A possible extrastriatal site of action of neuroleptic compounds is the limbic system, which is also rich in DA and ACh neurons. As for the effect of neuroleptics, however, a fundamental difference exists between striatal and limbic structures. It is found that chlorpromazine or haloperidol failed to enhance the liberation of ACh collected by means of a push-pull cannula from the septum or nucleus accumbens of the gallamine-immobilized cat. This is in contrast to their marked effect on the caudate nucleus, although the DA turnover in both regions was markedly accelerated, as estimated by the rise of homovanillic acid.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
