Abstract

PREVIOUS studies from these laboratories1 have shown that L-3,4-dihydroxyphenylalanine (L-dopa) does not undergo sulphoconjugation in vitro in the cytosol sulphating system of rat tissues whereas dopamine very readily yields a mixture of the 3- and 4-O-sulphates. These observations might therefore serve to explain earlier claims2 that sulphoconjugated dopamine constituted a significant proportion of the amine fraction extractable from rat tissues following the administration of 14C-labelled L-dopa and raises the question of the role of sulphoconjugation in dopamine metabolism. In man this may be of significance in L-dopa therapy in the treatment of Parkinson's disease since such conjugates might represent either intermediates or end products of metabolism.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call